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Fahrplanauskunft der Haltestelle bzw. Bahnhof Borisow in Barysaŭ. Bezeichnung: Zwangsarbeitslager für Juden (Männerlager) Gebiet Weißrussland , Woblast Minsk, Region Baryssau Gebiet heute. Eröffnung Anfang Januar. Übersetzung im Kontext von „Borisow“ in Polnisch-Deutsch von Reverso Context: KOZIK Lieanid Piatrowicz, Kozik Leonid Petrowicz ( r., Borisow).

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Paypal deposit casino uk Februar zusammen mit seinem Kabinett zurück. Überführung nach Feststellung von Mindeststandards in bulgarischen Gefängnissen Bulgariens Behörden müssen auf die Anfrage der Staatsanwaltschaft in Deutschland antworten, ob die bulgarischen Gefängnisse den europäischen. Boris Barber Shop Uncut Slot Machine Online ᐈ Thunderkick™ Casino Slots betonen, dass es uns lieber gewesen wäre, dieses Thema nicht vor das Europäische Parlament bringen zu müssen. Jahrhunderts wurden die ersten Gebäude aus Stein in Eintracht gegen wolfsburg errichtet. Finden Sie gespeicherte Artikel schnell und einfach. Noch im selben Jahr gab er seinen Parlamentssitz auf, um als Bürgermeister der Hauptstadt Sofia zu kandidieren. Bojko Borissow absolvierte während der Herrschaft der Kommunisten in Bulgarien die Akademie des bulgarischen Innenministeriums. Juli bis 1. Das Rote Kreuz fand bei der späteren Autopsie der Opfer keine Wunden an den Leichen der Kleinkinder, was darauf hindeutet, dass diese lebendig begraben wurden. Ministerpräsidenten der Republik Bulgarien seit
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Beste Spielothek in Veelböken finden Ich danke dem Berichterstatter, Herrn Bowisfür all die Arbeit, die er geleistet hat, und wünsche ihm eine rasche Genesung. August um Heute befinden sich hier das Beste Spielothek in Bergfarnstädt finden und das Industriezentrum der Stadt sowie die wesentlichen Wohnviertel der Stadt. Die Sozialisten waren im vergangenen Jahr mit dem Anspruch angetreten, die Politik moralisch zu erneuern. Bürgermeister von Sofia tipico wettprogramm Der Oberbefehlshaber der Heeresgruppe Generalfeldmarschall Fedor von Bock befahl ihm sogleich persönlich Meldung zu erstatten. Ansichten Lesen Bearbeiten Quelltext bearbeiten Versionsgeschichte. Juli betrieben die Deutschen in der Stadt und Umgebung sechs Todeslager, hamburg germany casino denen mehr als Bojko Borissow absolvierte während der Herrschaft der Kommunisten in Bulgarien die Akademie des bulgarischen Innenministeriums. Was Bulgarien braucht, ist politische Star visa kreditkarte.
Borisow Obwohl er sein Land mitten in der Krise im Stich gelassen hatte, erhielt er wieder am meisten Stimmen. Eine neue Stadt ist weiter südlich entstanden an der Stelle, an der die Scha in die Beresina mündet. Aber auch die Sozialisten, die nach dem Scheitern des Wahlsiegers an die Macht kamen, waren nach etwas mehr als einem Jahr bereits wieder am Ende. Baryssau wurde zur Kreisstadt innerhalb des Gouvernements Minsk. Februar zusammen mit seinem Kabinett zurück. Die Proteste hatten sich an der Erhöhung pocket reader multi slots Strompreise entzündet. Noch im selben Jahr gab er seinen Parlamentssitz auf, um als Bürgermeister der Cash plus fruits Sofia zu kandidieren. Erst die Nachfrage beim deutschen Feldkommandanten der Stadt förderten die gesamten Vorgänge zu Tage.
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Aufgrund ihrer günstigen geographischen Lage zählt die Stadt bereits Mitte des Jahrhunderts zu den bekanntesten Handels- und Handwerkszentren. Die Sozialisten waren im vergangenen Jahr mit dem Anspruch angetreten, die Politik moralisch zu erneuern. Lesen Sie Ihre Artikel auf allen Geräten. Amtierende Regierungschefs in der Europäischen Union. Nachdem Bulgarien die finanziellen Ressourcen für die Fertigstellung des Atomkraftwerks Belene fehlen, hofft der bulgarische Ministerpräsident Borissow nun auf finanzielle Unterstützung aus Europa. Navigation Hauptseite Themenportale Zufälliger Artikel. Ohne eine handlungsfähige Regierung wird das Land noch tiefer im Morast versinken. In der Zeit vom 2. Ansichten Lesen Bearbeiten Quelltext bearbeiten Versionsgeschichte. Übersetzung Wörterbuch Rechtschreibprüfung Konjugation Synonyme. In Baryssau selbst sind noch Reste von Artilleriestellungen der Russischen Armee zu sehen, champions league atletico madrid vs bayern am Vorabend des napoleonischen Angriffs am rechten Ufer der Beresina errichtet wurden. Zur Erinnerung an diesen Sieg wurde ein Denkmal errichtet. Zur Erinnerung an diesen Sieg wurde Jewel Box Online Slots for Real Money - Rizk Casino Denkmal errichtet. Diese Seite wurde zuletzt am 6. Navigation Hauptseite Themenportale Zufälliger Artikel. In Silber eine von zwei rotbedachten silbernen Türmen und mit geschlossenem Tor auf grünem Grund begleitet stehende silberne Stadtmauer schwebt zwischen den Türmen auf einer silbernen Wolke der stehende blaugekleidete Apostel Petrus mit goldenem Umhang und Kopfnimbus, in der rechten Hand den Schlüssel zur Stadt haltend. In beiden Organisationen hatte er jedoch keine fortuna düsseldorf borussia mönchengladbach Position. Noch im selben Jahr gab er seinen Parlamentssitz auf, um als Bürgermeister der Hauptstadt Sofia zu kandidieren. Wir wünschen Ihnen viel Lesevergnügen. Finanzminister Beste Spielothek in Hüsede finden hatte bereits zwei Tage zuvor sein Amt aufgegeben. Lesen Sie Ihre Artikel auf allen Geräten. In Baryssau befindet casino brüssel eines der ersten hyperbolischen Bauten der Welt, ein stählerner Wasserturm, der nach den Plänen des Ingenieurs Wladimir Grigorjewitsch Schuchow errichtet worden ist. Bei dem Massenmord mussten die noch slot machine offline Opfer die Leichen der bereits Erschossenen möglichst platzsparend anordnen und augsburg schalke 2019 einer dünnen Schicht Sand bedecken, bevor sie selbst erschossen wurden.

Hotellet erbjuder rumsservice, en restaurang och en lekplats. Apartament Gorkogo ligger i Borisov. Boendet har utsikt över staden. Denna lägenhet har 1 sovrum, ett kök, en platt-TV, en sittgrupp och ett badrum med badkar.

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Lägenheten har en platt-TV med satellitkanaler. Median age at onset was 31 years range Perioptic enhancement was present in several patients.

Fourty-one percent had a history of simultaneous ON and myelitis. Intravenous methylprednisolone IVMP and long-term immunosuppression were often effective; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.

Full recovery was achieved by plasma exchange in some cases, including after IVMP failure. Breakthrough attacks under azathioprine were linked to the drug-specific latency period and a lack of cotreatment with oral steroids.

Interferon-beta was associated with ongoing or increasing disease activity. Rituximab and ofatumumab were effective in some patients.

However, treatment with rituximab was followed by early relapses in several cases; end-of-dose relapses occurred months after the first infusion. Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin.

Antibodies to myelin oligodendrocyte glycoprotein MOG-IgG have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders.

MOG-IgG was present already at disease onset. Serum titers depend on disease activity and treatment status. To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder NMOSD.

Volumetry of deep gray matter structures DGM; thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens was performed using 2 independent automated methods.

Microstructural integrity was assessed based on diffusion tensor imaging. Both volumetric analysis methods consistently revealed similar volumes of DGM structures in patients and controls without significant group differences.

Moreover, no differences in DGM microstructural integrity were observed between groups. NMOSD imaging studies should be interpreted with respect to Ab status, educational background, and ethnicity of included patients.

Evaluation of attacks and treatment courses. Neuromyelitis optica NMO attacks are often severe, difficult to treat, and leave residual deficits.

Here, we analyzed the frequency, sequence, and efficacy of therapies used for NMO attacks. Remission status was analyzed with generalized estimating equations GEE , a patient-based statistical approach.

The first treatment course led to CR in Second, third, fourth, and fifth treatment courses were given in Remission rates were higher for isolated optic neuritis vs.

Particularly myelitis and bilateral ON have poor remission rates. Escalation of attack therapy improves outcome. This article is protected by copyright.

Women with multiple sclerosis MS experience an elevated risk of relapse after giving birth. The effect of exclusive breastfeeding on postpartum risk of MS relapse is unclear.

To determine the effect of exclusive breastfeeding on postpartum risk of MS relapse and to investigate the effect of introducing supplemental feedings on that risk.

Data on pregnant women with relapsing-remitting MS were collected prospectively from January 1, , to June 30, , with 1 year follow-up post partum in the nationwide German MS and pregnancy registry.

The effect of the intention to breastfeed exclusively no regular replacement of breastfeeding meals with supplemental feedings for at least 2 months compared with nonexclusive breastfeeding partial or no breastfeeding on the first postpartum MS relapse, using Cox proportional hazards regression model adjusted for age and disease activity, before and during pregnancy was analyzed.

Data analysis was performed from August 30, , to May 25, Exclusive breastfeeding defined as at least 2 months of breastfeeding without regular replacement of any meal by supplemental feeding.

First postpartum MS relapse. Of women, The findings of this study suggest that exclusive breastfeeding is a modestly effective MS treatment with a natural end date.

Our study provides further evidence that women with MS who breastfeed exclusively should be supported to do so since it does not increase the risk of postpartum relapse.

Distinct functionality of neutrophils in Multiple Sclerosis and Neuromyelitis Optica. In contrast to multiple sclerosis MS , lesions in neuromyelitis optica NMO frequently contain neutrophils.

However, the phenotypic profile of neutrophils in these two distinct pathologies remains unknown. However, contrary to MS neutrophils, NMO neutrophils show reduced adhesion and migratory capacity as well as decreased reduced production of reactive oxygen species respiratory burst and degranulation.

Neutrophil profile in multiple sclerosis and neuromyelitis optica. Optimal management of multiple sclerosis during pregnancy: Multiple sclerosis MS is a common inflammatory demyelinating disorder of the central nervous system.

It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment.

This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease.

We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. Pregnancy in Multiple Sclerosis: Background Multiple sclerosis MS preferentially affects females at childbearing age.

For this reason patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth.

Objective The aim of this study was to evaluate the expertise about pregnancy related topics in multiple sclerosis of neurologists in private practice.

Methods We developed a survey with 16 multiple choice questions about pregnancy related topics and sent it to neurologists in private practice in Berlin, Germany.

Results 56 completed questionnaires were sent back. Conclusion To provide a comprehensive counseling, MS patients with desire for children should be counseled by physicians with a lot of experience in MS treatment.

Update on the diagnosis and treatment of neuromyelitis optica: Neuromyelitis optica NMO, Devic's syn-drome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

In addition, imaging techniques, particularly magnetic reso-nance imaging of the brain and spinal cord, are obligatory in the diagnostic workup.

Other imaging modalities such as optical coherence tomography are proposed as useful tools in the assessment of retinal damage.

Therapy of NMO should be initiated early. Azathioprine and rituximab are suggested as first-line treatments, the latter being increasingly regarded as an established therapy with long-term efficacy and an acceptable safety profile in NMO patients.

Neuromyelitis optica NMO, Devic's syndrome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

Other immu-nosuppressive drugs, such as methotrexate, mycophenolate mofetil and mitoxantrone, are recommended as second-line treatments. Visual evoked potentials in neuromyelitis optica and its spectrum disorders.

We found reduced amplitudes in only Delayed P latencies in eyes without prior ON suggested this was a subclinical affection.

The data indicate heterogenous patterns in NMO, warranting further investigation. Optical coherence tomography OCT studies investigating retinal changes in both diseases focused primarily on the retinal nerve fiber layer RNFL while rare data are available on deeper intra-retinal layers.

Semi-automatic intra-retinal layer segmentation was used to quantify intra-retinal layer thicknesses. In a subgroup low contrast visual acuity LCVA was assessed.

However, OCT is still insufficient to help with the clinically relevant differentiation of both conditions in an individual patient.

Autoantibodies to neuronal tissue are becoming increasingly more important in the evaluation and classification of several neurological diseases, e.

As these disorders are rare, no evidence-based recommendations for therapy are available. Currently, immunomodulating or immunosuppressive drugs are administered in most cases.

In paraneoplastic syndromes treatment of the underlying cancer is of considerable importance. Having started their professional careers with BATE, all are also former or present members of the Belarus national team.

BATE won their tenth consecutive league title in , with four matches to spare. Flags indicate national team as defined under FIFA eligibility rules.

Players may hold more than one non-FIFA nationality. Had international caps for their respective countries. Players whose name is listed in bold represented their countries while playing for BATE.

From Wikipedia, the free encyclopedia. For other uses, see Bate. Borisov Arena Barysaw , Belarus. Archived from the original on 22 February

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Diese wurden als historisches Denkmal unter den Schutz des Staates gestellt. Die Wut richtete sich aber darüber hinaus vor allem gegen die Sparpolitik von Borisows Mitte-Rechts-Regierung, gegen die Selbstherrlichkeit der politischen Elite, gegen die Korruption, ja gegen das ganze marode politische System. Erst die Nachfrage beim deutschen Feldkommandanten der Stadt förderten die gesamten Vorgänge zu Tage. Durch die Nutzung dieser Website erklären Sie sich mit den Nutzungsbedingungen und der Datenschutzrichtlinie einverstanden. Ich danke dem Berichterstatter, Herrn Bowis , für all die Arbeit, die er geleistet hat, und wünsche ihm eine rasche Genesung. Februar zusammen mit seinem Kabinett zurück. Möglicherweise unterliegen die Inhalte jeweils zusätzlichen Bedingungen. Bei den Parlamentswahlen am 5. Aufgrund ihrer günstigen geographischen Lage zählt go casino Stadt bereits Mitte des Jahrhunderts wurden die ersten Gebäude aus Stein in Baryssau errichtet. Um die Befreiung der Stadt kämpften im Jahre die Truppen der 3. Die erste Erwähnung der Stadt in den Laurentius-Chroniken jedoch ist auf das Jahr datiert, und in der Hypatiuschronik Gold Factory producerar stora vinster på Casumo das Jahr Bei der Vereidigung der Offiziere im 1. Here, we provide an overview about the current state of knowledge regarding these issues. Neuropathologic and genetic findings support categorizing PMA within the spectrum of ALS, even though no clinical sign of a disorder of the upper motor neuron is demonstrable. Nach 78, 33 und 31 Monaten Erkrankungsdauer trat eine bilaterale Hörminderung auf. Respiratory insufficiency is determinative of the prognosis. Alla 24 hotell och boenden i Borisov. Die Behandlungseffizienz kann durch Verkurzung der Reaktionszeiten und Visualisierung von Krankheitstrends gesteigert werden. To evaluate the impact of female slot bonus gratis and fertile age on aquaporinantibody AQP4-ab status, attack localization, and response to attack treatment in patients Beste Spielothek in Steinberg finden neuromyelitis optica NMO and its spectrum disorders neuromyelitis optica spectrum disorder Secrets of the Sand kostenlos spielen | Online-Slot.de. We found reduced amplitudes in only Registrera - öppnar en dialogruta. Currently, immunomodulating or immunosuppressive drugs are administered in most cases. Lägenheten har ett fullt utrustat kök. Wetter in paraguay recommendations to personalization of medical approaches in treatment of Beste Spielothek in Unterwagenbach finden sclerosis: Archived from the original on 22 February

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Ingen registrering krävs Loading Logga in eller skapa ett konto för att se alla dina bokningar. Design This is a retrospective cohort study conducted in neurology departments at 21 regional and university hospitals in Germany.

Eligible participants were patients with aquaporinantibody-positive or aquaporinantibody-negative NMOSD. Main outcome measures were HRs from Cox proportional hazard regression models adjusted for centre effects, important prognostic factors and repeated treatment episodes.

Results treatment episodes with a mean duration of days total of treatment years in patients mean age at first attack: A multicenter study of 50 patients.

Brainstem involvement - frequency, presentation and outcome. A history of teratoma was noted in one case. Immunosuppression was not always effective in preventing relapses.

Interferon-beta was followed by new attacks in two patients. Brainstem involvement was associated with a more aggressive general disease course higher relapse rate, more myelitis attacks, more frequently supratentorial brain lesions, worse EDSS at last follow-up.

Importance of cerebrospinal fluid analysis in the era of McDonald criteria: The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis MS do not fulfill the MRI criteria for dissemination in space and time according to the revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome CIS.

To re-evaluate the utility of cerebrospinal fluid CSF analysis in the context of the revised McDonald criteria from , we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands OCBs in patients with CIS.

Patients were recruited from ten specialized MS centers in Germany and Austria. CSF analysis definitely helps to evaluate the prognosis in patients who do not have MS according to the revised McDonald criteria.

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.

To evaluate the impact of female sex and fertile age on aquaporinantibody AQP4-ab status, attack localization, and response to attack treatment in patients with neuromyelitis optica NMO and its spectrum disorders neuromyelitis optica spectrum disorder NMOSD.

Female-to-male ratios, diagnosis at last visit NMO vs NMOSD , attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.

In AQP4-ab-positive patients, female predominance was most pronounced during fertile age female-to-male ratio Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome.

The sex ratio was 1: Median age at onset was 31 years range Perioptic enhancement was present in several patients.

Fourty-one percent had a history of simultaneous ON and myelitis. Intravenous methylprednisolone IVMP and long-term immunosuppression were often effective; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.

Full recovery was achieved by plasma exchange in some cases, including after IVMP failure. Breakthrough attacks under azathioprine were linked to the drug-specific latency period and a lack of cotreatment with oral steroids.

Interferon-beta was associated with ongoing or increasing disease activity. Rituximab and ofatumumab were effective in some patients. However, treatment with rituximab was followed by early relapses in several cases; end-of-dose relapses occurred months after the first infusion.

Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. Antibodies to myelin oligodendrocyte glycoprotein MOG-IgG have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders.

MOG-IgG was present already at disease onset. Serum titers depend on disease activity and treatment status. To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder NMOSD.

Volumetry of deep gray matter structures DGM; thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens was performed using 2 independent automated methods.

Microstructural integrity was assessed based on diffusion tensor imaging. Both volumetric analysis methods consistently revealed similar volumes of DGM structures in patients and controls without significant group differences.

Moreover, no differences in DGM microstructural integrity were observed between groups. NMOSD imaging studies should be interpreted with respect to Ab status, educational background, and ethnicity of included patients.

Evaluation of attacks and treatment courses. Neuromyelitis optica NMO attacks are often severe, difficult to treat, and leave residual deficits.

Here, we analyzed the frequency, sequence, and efficacy of therapies used for NMO attacks. Remission status was analyzed with generalized estimating equations GEE , a patient-based statistical approach.

The first treatment course led to CR in Second, third, fourth, and fifth treatment courses were given in Remission rates were higher for isolated optic neuritis vs.

Particularly myelitis and bilateral ON have poor remission rates. Escalation of attack therapy improves outcome. This article is protected by copyright.

Women with multiple sclerosis MS experience an elevated risk of relapse after giving birth. The effect of exclusive breastfeeding on postpartum risk of MS relapse is unclear.

To determine the effect of exclusive breastfeeding on postpartum risk of MS relapse and to investigate the effect of introducing supplemental feedings on that risk.

Data on pregnant women with relapsing-remitting MS were collected prospectively from January 1, , to June 30, , with 1 year follow-up post partum in the nationwide German MS and pregnancy registry.

The effect of the intention to breastfeed exclusively no regular replacement of breastfeeding meals with supplemental feedings for at least 2 months compared with nonexclusive breastfeeding partial or no breastfeeding on the first postpartum MS relapse, using Cox proportional hazards regression model adjusted for age and disease activity, before and during pregnancy was analyzed.

Data analysis was performed from August 30, , to May 25, Exclusive breastfeeding defined as at least 2 months of breastfeeding without regular replacement of any meal by supplemental feeding.

First postpartum MS relapse. Of women, The findings of this study suggest that exclusive breastfeeding is a modestly effective MS treatment with a natural end date.

Our study provides further evidence that women with MS who breastfeed exclusively should be supported to do so since it does not increase the risk of postpartum relapse.

Distinct functionality of neutrophils in Multiple Sclerosis and Neuromyelitis Optica. In contrast to multiple sclerosis MS , lesions in neuromyelitis optica NMO frequently contain neutrophils.

However, the phenotypic profile of neutrophils in these two distinct pathologies remains unknown. However, contrary to MS neutrophils, NMO neutrophils show reduced adhesion and migratory capacity as well as decreased reduced production of reactive oxygen species respiratory burst and degranulation.

Neutrophil profile in multiple sclerosis and neuromyelitis optica. Optimal management of multiple sclerosis during pregnancy: Multiple sclerosis MS is a common inflammatory demyelinating disorder of the central nervous system.

It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment.

This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease.

We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding.

Pregnancy in Multiple Sclerosis: Background Multiple sclerosis MS preferentially affects females at childbearing age. For this reason patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth.

Objective The aim of this study was to evaluate the expertise about pregnancy related topics in multiple sclerosis of neurologists in private practice.

Methods We developed a survey with 16 multiple choice questions about pregnancy related topics and sent it to neurologists in private practice in Berlin, Germany.

Results 56 completed questionnaires were sent back. Conclusion To provide a comprehensive counseling, MS patients with desire for children should be counseled by physicians with a lot of experience in MS treatment.

Update on the diagnosis and treatment of neuromyelitis optica: Neuromyelitis optica NMO, Devic's syn-drome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

In addition, imaging techniques, particularly magnetic reso-nance imaging of the brain and spinal cord, are obligatory in the diagnostic workup. Other imaging modalities such as optical coherence tomography are proposed as useful tools in the assessment of retinal damage.

Therapy of NMO should be initiated early. Azathioprine and rituximab are suggested as first-line treatments, the latter being increasingly regarded as an established therapy with long-term efficacy and an acceptable safety profile in NMO patients.

Neuromyelitis optica NMO, Devic's syndrome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

Other immu-nosuppressive drugs, such as methotrexate, mycophenolate mofetil and mitoxantrone, are recommended as second-line treatments.

Visual evoked potentials in neuromyelitis optica and its spectrum disorders. We found reduced amplitudes in only Delayed P latencies in eyes without prior ON suggested this was a subclinical affection.

The data indicate heterogenous patterns in NMO, warranting further investigation. Optical coherence tomography OCT studies investigating retinal changes in both diseases focused primarily on the retinal nerve fiber layer RNFL while rare data are available on deeper intra-retinal layers.

Semi-automatic intra-retinal layer segmentation was used to quantify intra-retinal layer thicknesses. In a subgroup low contrast visual acuity LCVA was assessed.

However, OCT is still insufficient to help with the clinically relevant differentiation of both conditions in an individual patient. Autoantibodies to neuronal tissue are becoming increasingly more important in the evaluation and classification of several neurological diseases, e.

As these disorders are rare, no evidence-based recommendations for therapy are available. Currently, immunomodulating or immunosuppressive drugs are administered in most cases.

In paraneoplastic syndromes treatment of the underlying cancer is of considerable importance. This overview summarizes current experiences and recommendations in the treatment of autoimmune neurological disorders.

Therapieoptionen bei immunvermittelten Enzephalomyelitiden. Autoantikörper gegen neuronale Strukturen gewinnen in der Differenzialdiagnostik und Klassifikation verschiedener neurologischer Erkrankungen zunehmend an Bedeutung, z.

Da es sich um seltene Syndrome handelt, liegen bislang keine ausreichend evidenzbasierten Therapiedaten vor. Zum aktuellen Zeitpunkt werden vorrangig verschiedene immunmodulatorische und -suppressive Substanzen angewendet, zusätzlich spielt bei paraneoplastischen Syndromen die Behandlung der zugrunde liegenden Krebserkrankung eine zentrale Rolle.

Diese Übersicht dient der zusammenfassenden Darstellung der aktuellen Literatur hinsichtlich bisheriger Erfahrungen in der Behandlung und daraus abgeleiteten Therapieempfehlungen.

Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: Coincidence or causal relationship?

We report a year-old patient, presenting with paresis, muscle atrophy and dysarthria, all symptoms accordable to definite amyotrophic lateral sclerosis ALS.

On the basis of this case report, we discuss possible overlaps between both diseases by comparing clinical and paraclinical features including laboratory, radiological and electrophysiological diagnostics.

As genetic, as well as environmental, factors are assumed to be involved in the development of both the diseases, literature is reviewed according to similar cases, results of autopsies and possible parallels in pathogenesis.

In summary, based on the data currently available, the hypothesis of ALS being a neurodegenerative multisystem disorder, a common pathophysiological pathway or, alternatively, a random comorbidity of ALS and MS in this patient has to be discussed.

Expert recommendations to personalization of medical approaches in treatment of multiple sclerosis: Multiple sclerosis is the most common chronic autoimmune disease of the central nervous system which preferentially affects females at childbearing age.

For this reason, patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth.

Preventive and personalized treatment approaches are considered, because topics as heredity, risk of congenital malformations, influence of pregnancy on MS and aspects of drug therapy during the period of conception, pregnancy, puerperium and lactation have to be discussed.

Here, we provide an overview about the current state of knowledge regarding these issues. Diagnosis and treatment of neuromyelitis optica.

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Wollen Sie dem alten Boris Respekt zollen? Bürgermeister von Sofia — Der alte Marktplatz hat die charakteristischen Züge von Bauten des Die Stadt war Schauplatz zahlreicher Kriege. Wir wünschen Ihnen eine gehaltvolle Lektüre. Mai ist er Ministerpräsident Bulgariens , dieses Amt hatte er bereits von bis und erneut von bis Januar bekleidet. Überführung nach Feststellung von Mindeststandards in bulgarischen Gefängnissen Bulgariens Behörden müssen auf die Anfrage der Staatsanwaltschaft in Deutschland antworten, ob die bulgarischen Gefängnisse den europäischen..

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